Tovo P A, Lala R, Martino S, Pastorelli G, De Sanctis C
Department of Paediatrics, University of Turin, Italy.
Eur J Pediatr. 1991 Apr;150(6):400-2. doi: 10.1007/BF02093717.
A 14-year-old girl has been suffering from an isolated adrenocorticotropin hormone (ACTH) deficiency with secondary glucocorticoid deficiency and common variable immunodeficiency since the age of 6.6 years. Human corticotropin releasing hormone administration did not increase ACTH and cortisol levels, strongly suggesting a pituitary deficiency. Despite the profound humoral defect, severe infections have never developed and the antibody response to herpes viruses was intact. We speculate that the association between two rare disorders, simultaneously diagnosed 2 months after measles, is not coincidental but caused by close interactions between neuro-endocrine and immune systems.
一名14岁女孩自6.6岁起就一直患有孤立性促肾上腺皮质激素（ACTH）缺乏症，继发糖皮质激素缺乏症和常见变异型免疫缺陷。给予人促肾上腺皮质激素释放激素后，ACTH和皮质醇水平并未升高，强烈提示存在垂体功能缺陷。尽管存在严重的体液免疫缺陷，但从未发生过严重感染，且对疱疹病毒的抗体反应完好。我们推测，这两种罕见疾病在麻疹后2个月同时被诊断出，并非巧合，而是神经内分泌系统和免疫系统之间密切相互作用所致。
