病毒感染的染色质调控

Chromatin regulation of virus infection.

作者信息

Lieberman Paul M

机构信息

The Wistar Institute, Philadelphia, PA 19104, USA.

出版信息

Trends Microbiol. 2006 Mar;14(3):132-40. doi: 10.1016/j.tim.2006.01.001. Epub 2006 Feb 2.

DOI:10.1016/j.tim.2006.01.001

PMID:16458005

Abstract

Cellular chromatin forms a dynamic structure that maintains the stability and accessibility of the host DNA genome. Viruses that enter and persist in the nucleus must, therefore, contend with the forces that drive chromatin formation and regulate chromatin structure. In some cases, cellular chromatin inhibits viral gene expression and replication by suppressing DNA accessibility. In other cases, cellular chromatin provides essential structure and organization to the viral genome and is necessary for successful completion of the viral life cycle. Consequently, viruses have acquired numerous mechanisms to manipulate cellular chromatin to ensure viral genome survival and propagation.

摘要

细胞染色质形成一种动态结构，维持宿主DNA基因组的稳定性和可及性。因此，进入细胞核并在其中持续存在的病毒必须应对驱动染色质形成和调节染色质结构的各种力量。在某些情况下，细胞染色质通过抑制DNA可及性来抑制病毒基因表达和复制。在其他情况下，细胞染色质为病毒基因组提供必要的结构和组织，是病毒生命周期成功完成所必需的。因此，病毒已经获得了多种机制来操纵细胞染色质，以确保病毒基因组的存活和传播。