Jacobs Alice K
Section of Cardiology, Boston University Medical Center, Boston, Massachusetts 02118-2308, USA.
J Am Coll Cardiol. 2006 Feb 7;47(3 Suppl):S63-5. doi: 10.1016/j.jacc.2004.12.085.
During the past three decades, numerous reports from single-center databases, multicenter registries, and a few randomized trials in patients with ischemic heart disease (IHD) undergoing revascularization with both coronary artery bypass grafting and percutaneous coronary intervention have noted remarkably consistent gender differences in clinical, angiographic, and procedural factors and an increased morbidity and mortality in women. Explanations such as alternative markers of atherosclerosis and novel risk factors in women, gender-specific measures of left ventricular function, and the relationship between disorders more common in women with IHD and adverse cardiovascular outcomes are beginning to unfold.
在过去三十年中，来自单中心数据库、多中心登记处以及一些针对缺血性心脏病（IHD）患者进行冠状动脉旁路移植术和经皮冠状动脉介入治疗血运重建的随机试验的大量报告指出，在临床、血管造影和手术因素方面存在显著一致的性别差异，且女性的发病率和死亡率有所增加。诸如女性动脉粥样硬化的替代标志物和新的危险因素、左心室功能的性别特异性指标，以及IHD中女性更常见的疾病与不良心血管结局之间的关系等解释正开始逐渐明晰。
