Wein Alan J, Rackley Raymond R
University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA.
J Urol. 2006 Mar;175(3 Pt 2):S5-10. doi: 10.1016/S0022-5347(05)00313-7.
We reviewed current information regarding the updated definitions, prevalence, etiologies, disease burden, and management of OAB from a number of perspectives, including professional impact and patient quality of life.
Published literature and current treatment concepts were reviewed regarding the understanding and management of OAB.
OAB is a symptom syndrome including urinary urgency with or without urinary incontinence, usually with frequency and nocturia. Approximately 17% of the adult population experience OAB. There are evolving theories regarding its pathophysiology and the mechanism of action of the most commonly prescribed pharmacological therapy (antimuscarinic agents). Treatment primarily revolves around improving quality of life.
Behavioral therapy combined with pharmacological therapy often will bring about acceptable outcomes for patients with OAB. Modalities such as botulinum toxin injections, neuromodulation, and various surgical interventions also are showing encouraging results in more refractory patients.
我们从多个角度回顾了关于膀胱过度活动症（OAB）的最新定义、患病率、病因、疾病负担及管理的当前信息，包括专业影响和患者生活质量。
回顾了已发表的文献及当前关于OAB的认识和管理的治疗理念。
OAB是一种症状综合征，包括伴有或不伴有尿失禁的尿急，通常伴有尿频和夜尿症。约17%的成年人口患有OAB。关于其病理生理学及最常用药物治疗（抗毒蕈碱药物）的作用机制，有不断发展的理论。治疗主要围绕改善生活质量展开。
行为疗法联合药物疗法通常会给OAB患者带来可接受的治疗效果。肉毒杆菌毒素注射、神经调节及各种手术干预等方式在治疗更难治的患者方面也显示出令人鼓舞的结果。
