Hensley Paula L
Department of Psychiatry, Health Sciences Center, University of New Mexico School of Medicine, 2400 Tucker NE, 4th Floor, Albuquerque, 87131, USA.
J Affect Disord. 2006 May;92(1):117-24. doi: 10.1016/j.jad.2005.12.041. Epub 2006 Feb 3.
In the bereaved, approximately 40% meet criteria for major depression within a month of the death. At a year, approximately 15% of the bereaved are depressed and at 2 years, the figure is approximately 7%. Open-label trials of medication for bereavement-related depression have shown promising results for desipramine, nortriptyline, and bupropion SR. One double-blind controlled trial supports the use of nortriptyline, but interpersonal psychotherapy did no better than placebo. In all these trials, depressive symptoms improve more than bereavement symptoms. Effective open-label treatments for traumatic grief include paroxetine, nortriptyline, and a form of psychotherapy called traumatic grief treatment.
在丧亲者中，约40%在亲人去世后的一个月内符合重度抑郁症的标准。一年后，约15%的丧亲者患有抑郁症，到两年时，这一数字约为7%。针对与丧亲相关抑郁症的药物开放标签试验显示，去甲丙咪嗪、去甲替林和安非他酮缓释片有不错的效果。一项双盲对照试验支持使用去甲替林，但人际心理治疗并不比安慰剂效果更好。在所有这些试验中，抑郁症状的改善比丧亲症状的改善更明显。针对创伤性悲伤的有效开放标签治疗方法包括帕罗西汀、去甲替林，以及一种名为创伤性悲伤治疗的心理治疗形式。
