Zhong Jian, Yan Zhengchen, Liu Daoyan, Ni Yinxing, Zhao Zhigang, Zhu Shanjun, Tepel Martin, Zhu Zhiming
Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing, P.R. China.
J Lab Clin Med. 2006 Feb;147(2):91-5. doi: 10.1016/j.lab.2005.10.001.
To establish whether angiotensin-converting enzyme 2 (ACE2) gene A/G single nucleotide polymorphism is associated with hypertension in Chinese patients with metabolic syndrome. The study was conducted in 353 patients with metabolic syndrome. The alleles of the ACE2 A/G polymorphism, which is located on the X chromosome, were detected using polymerase chain reaction and subsequent cleavage by Alu I restriction endonuclease. G allele frequencies in patients with metabolic syndrome were 36.6% in female subjects and 43.4% in male subjects, respectively. Female patients with metabolic syndrome who carry the GG genotype had a significantly higher diastolic blood pressure compared with other genotypes. Multivariate logistic regression showed that female gender (P = 0.019) and carrying only the G allele (odds ratio 2.83 [95% CI 1.36 to 5.91]; P = 0.005) were significantly associated with increased diastolic blood pressure. It is concluded that the ACE2 A/G polymorphism is associated with hypertension in patients with metabolic syndrome.
旨在确定血管紧张素转换酶2（ACE2）基因A/G单核苷酸多态性是否与中国代谢综合征患者的高血压相关。该研究纳入了353例代谢综合征患者。采用聚合酶链反应及随后的Alu I限制性内切酶切割法检测位于X染色体上的ACE2 A/G多态性的等位基因。代谢综合征女性患者和男性患者中G等位基因频率分别为36.6%和43.4%。携带GG基因型的代谢综合征女性患者与其他基因型患者相比，舒张压显著更高。多因素逻辑回归分析显示，女性（P = 0.019）以及仅携带G等位基因（比值比2.83 [95%可信区间1.36至5.91]；P = 0.005）与舒张压升高显著相关。得出结论：ACE2 A/G多态性与代谢综合征患者的高血压相关。
