Jeng J R, Harn H J, Jeng C Y, Yueh K C, Shieh S M
Division of Cardiology, Tri-Service General Hospital, Taipei, Republic of China, Taiwan.
Am J Hypertens. 1997 May;10(5 Pt 1):558-61. doi: 10.1016/s0895-7061(97)00036-8.
Reports from different ethnic populations failed to show consistent findings on the association of hypertension with insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene. In this population association study in Chinese, we compared the distribution of the ACE genotypes and allele frequency in 150 healthy controls with normal blood pressure and 148 hypertensive patients categorized by age. Although the frequencies of homozygote deletion (DD) genotype and deletion allele were greater in Chinese with hypertension than in normotensive controls (0.23 vs 0.13 and 0.44 v 0.37, respectively), the differences were not significant by chi2 analysis (P = .07 and .09, respectively). Furthermore, we did not find the trend of decreasing number of DD genotype in older hypertensive Chinese patients. The results indicated a much lower prevalence of ACE/DD genotype in Chinese than in Caucasians and a modest association between I/D polymorphism of the ACE gene and hypertension in Chinese.
来自不同种族人群的报告未能就高血压与血管紧张素I转换酶（ACE）基因插入/缺失（I/D）多态性之间的关联得出一致的研究结果。在这项针对中国人的群体关联研究中，我们比较了150名血压正常的健康对照者和148名按年龄分类的高血压患者的ACE基因型分布及等位基因频率。尽管中国高血压患者中纯合子缺失（DD）基因型和缺失等位基因的频率高于血压正常的对照者（分别为0.23对0.13以及0.44对0.37），但经卡方分析，差异无统计学意义（P值分别为0.07和0.09）。此外，我们未发现老年中国高血压患者中DD基因型数量减少的趋势。结果表明，中国人中ACE/DD基因型的患病率远低于白种人，且ACE基因的I/D多态性与中国人群的高血压之间存在一定关联。
