基于（18）F的放射性示踪剂的正电子发射断层扫描（PET）成像。
Positron emission tomography (PET) imaging with (18)F-based radiotracers.
作者信息
Alauddin Mian M
机构信息
Department of Experimental Diagnostic Imaging, The University of Texas MD Anderson Cancer Center Houston, TX 77030, USA.
出版信息
Am J Nucl Med Mol Imaging. 2012;2(1):55-76. Epub 2011 Dec 15.
Abstract
Positron Emission Tomography (PET) is a nuclear medicine imaging technique that is widely used in early detection and treatment follow up of many diseases, including cancer. This modality requires positron-emitting isotope labeled biomolecules, which are synthesized prior to perform imaging studies. Fluorine-18 is one of the several isotopes of fluorine that is routinely used in radiolabeling of biomolecules for PET; because of its positron emitting property and favorable half-life of 109.8 min. The biologically active molecule most commonly used for PET is 2-deoxy-2-(18)F-fluoro-β-D-glucose ((18)F-FDG), an analogue of glucose, for early detection of tumors. The concentrations of tracer accumulation (PET image) demonstrate the metabolic activity of tissues in terms of regional glucose metabolism and accumulation. Other tracers are also used in PET to image the tissue concentration. In this review, information on fluorination and radiofluorination reactions, radiofluorinating agents, and radiolabeling of various compounds and their application in PET imaging is presented.
摘要
正电子发射断层扫描（PET）是一种核医学成像技术，广泛应用于包括癌症在内的多种疾病的早期检测和治疗随访。这种成像方式需要正电子发射同位素标记的生物分子，这些分子在进行成像研究之前就已合成。氟-18是氟的几种同位素之一，常用于生物分子的PET放射性标记；因其具有正电子发射特性且半衰期为109.8分钟，较为理想。PET最常用的生物活性分子是2-脱氧-2-（18）F-氟-β-D-葡萄糖（（18）F-FDG），它是葡萄糖的类似物，用于肿瘤的早期检测。示踪剂积累浓度（PET图像）根据区域葡萄糖代谢和积累情况显示组织的代谢活性。其他示踪剂也用于PET以成像组织浓度。在本综述中，介绍了有关氟化和放射性氟化反应、放射性氟化剂以及各种化合物的放射性标记及其在PET成像中的应用的信息。
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