Wondisford Fredric E
Division of Metabolism, Department of Pediatrics, Johns Hopkins University Medical School, Baltimore, Maryland 21287, USA.
Cell Metab. 2006 Feb;3(2):81-2. doi: 10.1016/j.cmet.2006.01.008.
The classic role of bile acids is as a key component of cholesterol homeostasis. New evidence recently published in Nature (Watanabe et al., 2006), however, describes a bile acid signaling pathway that controls energy expenditure through induction of thyroid hormone signaling pathways. This work may point to new approaches to tissue-specific metabolic regulation.
胆汁酸的经典作用是作为胆固醇稳态的关键组成部分。然而，最近发表在《自然》杂志上的新证据（渡边等人，2006年）描述了一种胆汁酸信号通路，该通路通过诱导甲状腺激素信号通路来控制能量消耗。这项研究可能指向组织特异性代谢调节的新方法。
