Bideci Aysun, Camurdan M Orhun, Cinaz Peyami, Demirel Fatma
Department of Pediatric Endocrinology, Gazi University, Ankara, Turkey.
J Pediatr Endocrinol Metab. 2005 Dec;18(12):1433-9. doi: 10.1515/jpem.2005.18.12.1433.
There is a strong relationship between ghrelin, insulin, glucose and IGF-I/IGFBP-3 metabolism. This aim of this study was to investigate ghrelin level, and its relationship with IGF-I and IGFBP-3 levels in children with type 1 diabetes mellitus (DM1). Twenty-seven children with DM1 and 25 healthy controls were investigated. Ghrelin levels were similar, and IGF-I and IGFBP-3 levels were lower, in prepubertal and pubertal patients compared to controls. In the patient group, ghrelin levels were negatively correlated with chronological age, height, weight, pubertal status and IGF-I, but had no correlation with fasting glucose, HbA1c, insulin dose, duration of insulin therapy, and IGFBP-3 levels. Similar ghrelin levels in patients compared to controls may suggest that ghrelin levels remain unchanged in children with DM1, or that altered ghrelin levels at diagnosis recover as a consequence of insulin therapy. The lack of correlation of serum ghrelin levels with fasting plasma glucose, HbA1c and insulin dose suggests that ghrelin level is not affected by these parameters. Decreased IGF-I level and its negative correlation with ghrelin are compatible with previous findings.
胃饥饿素、胰岛素、葡萄糖与胰岛素样生长因子-I/胰岛素样生长因子结合蛋白-3代谢之间存在密切关系。本研究旨在调查1型糖尿病（DM1）患儿的胃饥饿素水平及其与胰岛素样生长因子-I和胰岛素样生长因子结合蛋白-3水平的关系。对27例DM1患儿和25例健康对照者进行了调查。与对照组相比，青春期前和青春期患者的胃饥饿素水平相似，而胰岛素样生长因子-I和胰岛素样生长因子结合蛋白-3水平较低。在患者组中，胃饥饿素水平与实际年龄、身高、体重、青春期状态和胰岛素样生长因子-I呈负相关，但与空腹血糖、糖化血红蛋白、胰岛素剂量、胰岛素治疗时间和胰岛素样生长因子结合蛋白-3水平无关。与对照组相比，患者的胃饥饿素水平相似，这可能表明DM1患儿的胃饥饿素水平保持不变，或者诊断时改变的胃饥饿素水平因胰岛素治疗而恢复。血清胃饥饿素水平与空腹血糖、糖化血红蛋白和胰岛素剂量缺乏相关性，表明胃饥饿素水平不受这些参数的影响。胰岛素样生长因子-I水平降低及其与胃饥饿素的负相关与先前的研究结果一致。
