Hale Clifford S
Jackson National Life Insurance Company, 1 Corporate Way, Lansing, MI 48951, USA.
J Insur Med. 2005;37(4):272-82.
There is solid evidence linking obstructive sleep apnea (OSA) to cardiovascular mortality. Although it has yet to be scientifically proven that OSA causes cardiovascular disease, many investigators consider it an independent cardiovascular risk factor. Its impact on the cardiovascular mortality risk of a given applicant varies depending upon the severity of the condition, compliance with treatment, and the applicant's specific cardiovascular milieu. This review is aimed at making mortality risk assessment more accurate by describing what is known of the physiologic mechanisms by which OSA may influence cardiovascular mortality and providing an appreciation for the magnitude of this risk. In doing so, an argument supporting OSA as a cause for cardiovascular disease and mortality emerges.
有确凿证据表明阻塞性睡眠呼吸暂停（OSA）与心血管疾病死亡率相关。尽管尚未科学证明OSA会导致心血管疾病，但许多研究人员认为它是一个独立的心血管危险因素。其对特定申请人心血管疾病死亡风险的影响因病情严重程度、治疗依从性以及申请人的特定心血管环境而异。本综述旨在通过描述已知的OSA可能影响心血管疾病死亡率的生理机制，并让人们了解这种风险的程度，从而使死亡风险评估更加准确。在此过程中，支持OSA作为心血管疾病和死亡原因的观点逐渐显现。
