Daidone M G, Silvestrini R, D'Errico A, Di Fronzo G, Benini E, Mancini A M, Garbisa S, Liotta L A, Grigioni W F
Oncologia Sperimentale C. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
Int J Cancer. 1991 Jun 19;48(4):529-32. doi: 10.1002/ijc.2910480409.
In 187 node-negative breast cancers, the expression of laminin receptors and collagenase IV was directly related in 52% of cases, independently of pathological (tumor size and histology) and biological (estrogen receptors and proliferative activity) features. Moreover, the presence of laminin receptors and collagenase IV did not appear to influence tumor proliferative activity, evaluated as 3H-thymidine labelling index. In this case series, relapse-free survival and overall survival at 6 years were significantly affected by tumor size, hormone receptor status and proliferative activity. Conversely, high levels of laminin receptors and collagenase IV failed to influence relapse-free or overall survival, whereas they were strong indicators of local-regional diffusion of the disease.
在187例淋巴结阴性乳腺癌中，52%的病例中层粘连蛋白受体与IV型胶原酶的表达直接相关，且与病理特征（肿瘤大小和组织学类型）及生物学特征（雌激素受体和增殖活性）无关。此外，层粘连蛋白受体和IV型胶原酶的存在似乎并未影响肿瘤增殖活性（以3H-胸腺嘧啶核苷标记指数评估）。在该病例系列中，6年无复发生存率和总生存率受肿瘤大小、激素受体状态和增殖活性的显著影响。相反，高水平的层粘连蛋白受体和IV型胶原酶未能影响无复发生存率或总生存率，然而它们是疾病局部区域扩散的有力指标。
