Fernandez-Tresguerres Hernández Jesus A
An R Acad Nac Med (Madr). 2005;122(2):341-55; discussion 355-60.
Monosodium glutamate is a substance widely used as flavouring agent in the whole world. It is considered to be innocuos by the health agencies of North America and Europe. The effects of the oral administration of two dosages of MSG during the second half of pregnancy and all The developmental process of pups on appetite control and various hormones has been analysed in rats. Effects have been compared with the neonatal parenteral administration of the same compound. The structure of the arcuate nucleus of the hypothalamus has been investigated as well as plasma levels of GH, IGF-1 and leptin and its influence on food consumption. Measurements were performed at 30 and 90 days of life. A nearly total destruction of the arcuate nucleus can be observed with the parenteral administration of MSG but also with the highest oral dose. Significant reductions can be seen in plasma GH and IGF 1 levels at 30 days of life, that are partially recovered at 90 days. Plasma leptin levels are significantly reduced at 90 days of life with the two oral doses together with a significant increase in food intake. In conclussion, oral administration of MSG during pregnancy and development in rats is able to significantly affect hypothalamic control of various hormones and increases appetite.
味精是一种在全球广泛用作调味剂的物质。北美和欧洲的卫生机构认为它是无害的。在大鼠中，分析了在妊娠后半期口服两种剂量的味精以及幼崽整个发育过程对食欲控制和各种激素的影响。已将这些影响与同一种化合物的新生儿肠胃外给药进行了比较。对下丘脑弓状核的结构以及生长激素（GH）、胰岛素样生长因子-1（IGF-1）和瘦素的血浆水平及其对食物消耗的影响进行了研究。在出生后30天和90天进行了测量。肠胃外给予味精以及口服最高剂量时，均可观察到弓状核几乎完全被破坏。出生后30天时，血浆GH和IGF-1水平显著降低，在90天时部分恢复。两种口服剂量在出生后90天时血浆瘦素水平显著降低，同时食物摄入量显著增加。总之，在大鼠妊娠和发育期间口服味精能够显著影响下丘脑对各种激素的控制并增加食欲。
