Ueda Jun-ya, Imamura Lisa, Tezuka Yasuhiro, Tran Quan L, Tsuda Masaaki, Kadota Shigetoshi
Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Bioorg Med Chem. 2006 May 15;14(10):3571-4. doi: 10.1016/j.bmc.2006.01.023. Epub 2006 Feb 7.
Agarwood, one of the valuable non-timber products in tropical forest, is a fragrant wood, whose ethereal fragrance has been prized in Asia for incense in ceremony, as well as sedatives in traditional medicine. We separated the 70% EtOH extract of Vietnamese agarwood, which showed significant induction effect on brain-derived neurotrophic factor (BDNF) mRNA expression in rat cultured neuronal cells, to isolate a new compound and a 2-(2-phenylethyl)chromone derivative. The new compound was determined to be a spirovetivane-type sesquiterpene, (4R,5R,7R)-1(10)-spirovetiven-11-ol-2-one, by spectroscopic data and showed induction effect of BDNF mRNA.
沉香是热带森林中珍贵的非木材产品之一，是一种香木，其淡雅的香气在亚洲被用于仪式焚香以及传统医学中的镇静剂。我们分离了越南沉香的70%乙醇提取物，该提取物对大鼠培养神经元细胞中脑源性神经营养因子（BDNF）mRNA表达具有显著的诱导作用，以分离出一种新化合物和一种2-(2-苯乙基)色酮衍生物。通过光谱数据确定该新化合物为一种螺岩兰草烷型倍半萜，即(4R,5R,7R)-1(10)-螺岩兰草烯-11-醇-2-酮，并显示出对BDNF mRNA的诱导作用。
