Carroll Lisa, Hannawi Suad, Marwick Thomas, Thomas Ranjeny
Centre for Immunology and Cancer Research, Princess Alexandra Hospital, University of Queensland, Brisbane, Queensland, Australia.
Wien Med Wochenschr. 2006 Jan;156(1-2):42-52. doi: 10.1007/s10354-005-0242-9.
Cardiovascular (CV) disease is increased in patients with chronic inflammatory disease, including rheumatoid arthritis (RA). Furthermore it has become clear at a pathophysiological level, that atherosclerosis has striking similarities with autoimmune disease. This realization has come at a time of paradigm shift in how rheumatologists manage RA, with the availability of biological agents targeting key inflammatory cytokines. This review will focus on the possible causes of increased vascular disease in RA, including the role of traditional CV risk factors. Mechanisms potentially at play, such as C-reactive protein (CRP), altered coagulation, and cyclooxygenase (COX)-2 inhibitors will be covered in brief. The receptor for advanced glycation end products (RAGE) has been identified as a candidate molecule influencing response to ongoing inflammation and autoimmunity. There will be a focus on the role of RAGE in CV disease and RA. As has been the case with many novel molecules, functional polymorphisms are thought to alter disease expression and assist us in coming to terms with the biological activities of the parent molecule. The review will conclude with a discussion of the potential role of the RAGE Glycine 82 Serine polymorphism.
心血管（CV）疾病在包括类风湿关节炎（RA）在内的慢性炎症性疾病患者中有所增加。此外，在病理生理层面已经明确，动脉粥样硬化与自身免疫性疾病有显著相似之处。这一认识是在风湿病学家管理RA的模式发生转变之际出现的，此时有了针对关键炎症细胞因子的生物制剂。本综述将聚焦于RA中血管疾病增加的可能原因，包括传统CV危险因素的作用。将简要介绍可能起作用的机制，如C反应蛋白（CRP）、凝血改变和环氧化酶（COX）-2抑制剂。晚期糖基化终产物受体（RAGE）已被确定为影响对持续炎症和自身免疫反应的候选分子。将重点讨论RAGE在CV疾病和RA中的作用。与许多新分子一样，功能多态性被认为会改变疾病表现，并帮助我们理解母体分子的生物学活性。综述将以讨论RAGE甘氨酸82丝氨酸多态性的潜在作用作为结尾。
