Health and Social Research Center, Universidad de Castilla-La Mancha, 16171 Cuenca, Spain.
Universidad Politécnica y Artística del Paraguay, 001518 Asuncion, Paraguay.
Int J Environ Res Public Health. 2020 Sep 22;17(18):6936. doi: 10.3390/ijerph17186936.
Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the association of arterial stiffness measured by pulse wave velocity and atherosclerosis measured by carotid intima media thickness with skin autofluorescence. A systematic search was performed using: MEDLINE (PubMed), SCOPUS, and Web of Science, until 30 March 2020. Cross-sectional studies or baseline data from prospective longitudinal studies were considered. The DerSimonian and Laird method was used to calculate the pooled estimates of correlation coefficients and the corresponding 95% confidence intervals (CI) for the association of pulse wave velocity and carotid intima media thickness with skin autofluorescence. Twenty-five studies were included in the systematic review and meta-analysis, including 6306 subjects. The pooled correlation coefficient was 0.25 (95% CI: 0.18, 0.31) for pulse wave velocity and skin autofluorescence, and 0.31 (95% CI: 0.25, 0.38) for carotid intima media thickness and skin autofluorescence. This systematic review and meta-analysis provide a synthesis of the evidence showing a positive weak association of pulse wave velocity and carotid intima media thickness with skin autofluorescence.
有证据表明，晚期糖基化终产物与不同的心血管疾病亚临床过程之间存在关联，例如动脉僵硬和动脉粥样硬化。通过这项系统评价和荟萃分析，我们旨在综合评估动脉僵硬（通过脉搏波速度测量）和动脉粥样硬化（通过颈动脉内膜中层厚度测量）与皮肤自发荧光之间的关联的证据。使用以下数据库进行了系统搜索：MEDLINE（PubMed）、SCOPUS 和 Web of Science，直到 2020 年 3 月 30 日。纳入了横断面研究或前瞻性纵向研究的基线数据。使用 DerSimonian 和 Laird 方法计算脉搏波速度和颈动脉内膜中层厚度与皮肤自发荧光之间关联的相关系数的合并估计值及其相应的 95%置信区间（CI）。这项系统评价和荟萃分析纳入了 25 项研究，共 6306 名受试者。脉搏波速度与皮肤自发荧光之间的合并相关系数为 0.25（95%CI：0.18，0.31），颈动脉内膜中层厚度与皮肤自发荧光之间的合并相关系数为 0.31（95%CI：0.25，0.38）。这项系统评价和荟萃分析综合了证据，表明脉搏波速度和颈动脉内膜中层厚度与皮肤自发荧光之间存在正相关的弱关联。
