Wallace Chris, Chapman Juliet M, Clayton David G
Department of Clinical Pharmacology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom.
Am J Hum Genet. 2006 Mar;78(3):498-504. doi: 10.1086/500562. Epub 2006 Jan 5.
Selective genotyping is used to increase efficiency in genetic association studies of quantitative traits by genotyping only those individuals who deviate from the population mean. However, selection distorts the conditional distribution of the trait given genotype, and such data sets are usually analyzed using case-control methods, quantitative analysis within selected groups, or a combination of both. We show that Hotelling's T(2) test, recently proposed for association studies of one or several tagging single-nucleotide polymorphisms in a prospective (i.e., trait given genotype) design, can also be applied to the retrospective (i.e., genotype given trait) selective-genotyping design, and we use simulation to demonstrate its improved power over existing methods.
选择性基因分型用于通过仅对那些偏离群体均值的个体进行基因分型来提高数量性状遗传关联研究的效率。然而，选择会扭曲给定基因型下性状的条件分布，并且此类数据集通常使用病例对照方法、选定组内的定量分析或两者结合的方法进行分析。我们表明，最近提出的用于前瞻性（即给定基因型的性状）设计中一个或几个标签单核苷酸多态性关联研究的霍特林T(2)检验，也可应用于回顾性（即给定性状的基因型）选择性基因分型设计，并且我们通过模拟证明其相对于现有方法具有更高的检验效能。
