Zhang Yongzhong, Yu Longjiang, Ao Mingzhang, Jin Wenwen
School of Life Science & Technology, Huazhong University of Science & Technology, 430074 Wuhan, PR China.
J Ethnopharmacol. 2006 Apr 21;105(1-2):274-9. doi: 10.1016/j.jep.2005.12.013. Epub 2006 Feb 8.
Maca (Lepidium meyenii Walp.) is a cruciferous plant from the Andes of Peru. The root of Maca is traditionally employed for its supposed properties in aphrodisiacs and improving fertility, it also has been widely used to help alleviate the symptoms of menopause. The purpose of this study was to evaluate the effect of ethanol extract of Maca on postmenopausal osteoporosis in ovariectomized rats. Female Sprague-Dawley rats were divided into four groups: Sham-operated and ovariectomized groups were fed with equivolume of distilled water, and the remaining ovariectomized groups were orally administrated with ethanol extract of Maca at 0.096 and 0.24 g/kg for 28 weeks. The findings derived from the basis of bone mineral density, biomechanical, biochemical and histopathological parameters indicated that higher dose of ethanol extract of Maca was effective in the prevention of estrogen deficient bone loss.
玛卡（Lepidium meyenii Walp.）是一种来自秘鲁安第斯山脉的十字花科植物。玛卡根传统上因其所谓的壮阳和提高生育能力的特性而被使用，它也被广泛用于帮助缓解更年期症状。本研究的目的是评估玛卡乙醇提取物对去卵巢大鼠绝经后骨质疏松症的影响。将雌性Sprague-Dawley大鼠分为四组：假手术组和去卵巢组给予等量蒸馏水，其余去卵巢组分别以0.096和0.24 g/kg的剂量口服玛卡乙醇提取物，持续28周。基于骨密度、生物力学、生化和组织病理学参数的研究结果表明，较高剂量的玛卡乙醇提取物对预防雌激素缺乏导致的骨质流失有效。
