Hyams K C, Hussain M A, al-Arabi M A, al-Huda Atallah N, el-Tigani A, McCarthy M C
U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.
J Med Virol. 1991 Feb;33(2):73-6. doi: 10.1002/jmv.1890330202.
Eighty consecutive cases of acute viral hepatitis and 80 controls selected from a public pediatric clinic were entered into a study of acute sporadic hepatitis in Khartoum, Sudan. Study subjects were 14 years of age or younger and were mainly from a low socioeconomic level. Non-A, non-B hepatitis was diagnosed by exclusion in 35 (43.8%) patients, hepatitis A in 27 (33.8%), acute hepatitis B in 8 (10.0%), possible Epstein-Barr virus (EBV) hepatitis in 1 patient; and dual hepatitis A and B infection in 1 patient. Eight acute cases were positive for HBsAg but negative for anti-HBc IgM and anti-HAV IgM. Delta hepatitis was not identified in any study subject. A household case of jaundice and acquaintance with an individual outside of the household with jaundice during the prior 6 months were associated with non-A, non-B hepatitis. There was no association between parenteral exposure and non-A, non-B hepatitis. These findings suggest that enterically transmitted non-A, non-B hepatitis may be a major cause of acute sporadic hepatitis in children in this area, as well as a cause of epidemic hepatitis.
从苏丹喀土穆一家公共儿科诊所选取了80例连续的急性病毒性肝炎病例和80名对照，纳入一项关于急性散发性肝炎的研究。研究对象为14岁及以下儿童，主要来自社会经济水平较低的群体。通过排除法诊断出35例（43.8%）患者为非甲非乙型肝炎，27例（33.8%）为甲型肝炎，8例（10.0%）为急性乙型肝炎，1例可能为EB病毒（EBV）肝炎，1例为甲型和乙型肝炎双重感染。8例急性病例HBsAg呈阳性，但抗-HBc IgM和抗-HAV IgM呈阴性。在任何研究对象中均未发现丁型肝炎。家庭黄疸病例以及在过去6个月内与家庭外黄疸患者相识与非甲非乙型肝炎有关。肠道外接触与非甲非乙型肝炎之间无关联。这些发现表明，经肠道传播的非甲非乙型肝炎可能是该地区儿童急性散发性肝炎的主要原因，也是流行性肝炎的病因之一。
