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[The effect of serum rich in platelet-released growth factors on proliferation of rat osteoblast in vitro].

作者信息

Song Yang, Gong Ping, Wang Lei, Chao Yon-lie

机构信息

Department of Prosthodontics, West China Stomatological Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Jan;37(1):40-3.

PMID:16468638
Abstract

OBJECTIVE

To study the effect of serum rich in platlelet-released growth factors on the biological functions of rat osteoblast.

METHODS

Rat osteoblasts were isolated from parietal bone of fetal Spraque-Dawley (SD) rat. Platelet-rich plasma(PRP) and platelet-poor plasma (PPP) obtained from healthy SD rat were activated by thrombin to get serum rich in growth factors (SRGF) or serum poor in growth factors (SPGF). The cells were treated with 1.25%, 2.5%, 5% SRGF or SPGF, and cellular mitogenic activity was evaluated by thiazoly blue (MTT) colorimetric assay. Results When compared with SPGF at the same concentration, SRGF promoted the proliferation of rat osteoblast significantly (P = 0.002 - 0.004), and the proliferation seemed to correlate with the concentration of SRGF (Spearman's correlation coefficient, r(s) = 0.834).

CONCLUSION

SRGF is capable of upregulating the proliferation of rat osteoblast.

摘要

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