Giorgi O, Orlandi M, Lecca D, Corda M G
Department of Experimental Biology, University of Cagliari, Italy.
Eur J Pharmacol. 1991 Feb 14;193(3):363-5. doi: 10.1016/0014-2999(91)90152-g.
The repeated administration of pentylenetetrazol (PTZ) at a subconvulsant dose (30 mg/kg i.p., three times a week for nine weeks) produced kindling in 90% of rats under treatment. Pretreatment with the N-methyl-D-aspartate receptor antagonist, MK-801 (1 mg/kg i.p., 40 min before PTZ), prevented the behavioral manifestation (i.e. motor seizures) as well as the development of kindling. In fact, convulsions were not observed in rats pretreated with MK-801 either during the chronic PTZ administration or when challenged with PTZ three and 10 days after completion of the chronic treatment. The results suggest an involvement of excitatory amino acid neurotransmission in PTZ kindling.
以亚惊厥剂量（腹腔注射30毫克/千克，每周三次，共九周）反复给予戊四氮（PTZ）可使90%接受治疗的大鼠产生点燃效应。用N-甲基-D-天冬氨酸受体拮抗剂MK-801（腹腔注射1毫克/千克，在PTZ注射前40分钟）进行预处理，可预防行为表现（即运动性癫痫发作）以及点燃效应的发展。事实上，在慢性给予PTZ期间，或在慢性治疗完成后三天和十天用PTZ激发时，用MK-801预处理的大鼠均未观察到惊厥。结果表明兴奋性氨基酸神经传递参与了PTZ点燃效应。
