Unak T, Unak P
Faculty of Science, Department of Chemistry, Ege University, Bornova-Izmir, Turkey.
Int J Rad Appl Instrum A. 1991;42(3):291-5. doi: 10.1016/0883-2889(91)90091-e.
In this study the microscopic energy absorption from Auger electrons of iodine-125 in colloid of two different thyroid models, which represent the normal and thyrotoxic thyroid glands, was theoretically calculated. These calculations were based on the method recently given by Unak (1987; Nucl. Intrum. Meth. Phys. Res. A255, 274) and the Auger electron spectrum given by Charlton and Booz (1981; Radiat. Res. 87, 10). Subsequently the range of highest energy Auger electrons of iodine-125 in thyroidal colloid was found to be about 72 microns. This range is considerably shorter than the radius of a normal thyroid follicle, about 150 microns, but is considerably longer than the 25 microns radius of a thyrotoxic thyroid follicle. On the other hand, the comparison of dose distributions in two different thyroid models showed that the similar activity of iodine-125 per gram of thyroid tissue is able to produce more radiotoxic effects on the thyrotoxic follicular cells.
在本研究中，理论计算了碘 - 125的俄歇电子在两种不同甲状腺模型的胶体中的微观能量吸收，这两种模型分别代表正常甲状腺和甲状腺毒症甲状腺。这些计算基于Unak（1987年；《核仪器方法：物理研究A》第255卷，第274页）最近给出的方法以及Charlton和Booz（1981年；《辐射研究》第87卷，第10页）给出的俄歇电子能谱。随后发现碘 - 125在甲状腺胶体中能量最高的俄歇电子的射程约为72微米。该射程明显短于正常甲状腺滤泡的半径，约150微米，但明显长于甲状腺毒症甲状腺滤泡25微米的半径。另一方面，两种不同甲状腺模型中剂量分布的比较表明，每克甲状腺组织中相似活性的碘 - 125能够对甲状腺毒症滤泡细胞产生更大的放射毒性作用。
