Kahn Susan R
Department of Medicine, McGill University, and Center for Clinical Epidemiology & Community Studies, Sir Mortimer B. Davis Jewish General Hospital, 3755 Cote Sainte-Catherine, Room A-127, Montreal, Quebec, Canada H3T 1E2.
J Thromb Thrombolysis. 2006 Feb;21(1):41-8. doi: 10.1007/s11239-006-5574-9.
The postthrombotic syndrome (PTS) is the most common complication of deep venous thrombosis (DVT) yet has received little attention from clinicians and researchers. Clinically, PTS is characterized by chronic pain, swelling, heaviness and other signs in the affected limb. In severe cases, venous ulcers may develop. PTS is burdensome and costly to patients and society because of its high prevalence, severity and chronicity. Preventing DVT with the use of effective thromboprophylaxis in high-risk patients and settings and minimizing the risk of ipsilateral DVT recurrence are likely to reduce the frequency of PTS. Compression stockings worn daily after DVT appear to reduce the incidence and severity of PTS but questions regarding their use and effectiveness remain. Future research should focus on identifying patients at high risk for PTS, assessing the role of thrombolysis in preventing PTS and evaluating the optimal use of compression stockings in preventing and treating PTS. In addition, new therapies to treat PTS should be sought and evaluated.
血栓形成后综合征（PTS）是深静脉血栓形成（DVT）最常见的并发症，但临床医生和研究人员对其关注甚少。临床上，PTS的特征是患肢出现慢性疼痛、肿胀、沉重感及其他症状。严重时，可能会出现静脉溃疡。由于其高患病率、严重性和慢性病程，PTS给患者和社会带来了沉重负担和高昂成本。在高危患者和环境中使用有效的血栓预防措施来预防DVT，并将同侧DVT复发风险降至最低，可能会减少PTS的发生频率。DVT后每天穿着压力袜似乎可降低PTS的发生率和严重程度，但关于其使用和有效性仍存在疑问。未来的研究应聚焦于识别PTS高危患者、评估溶栓在预防PTS中的作用以及评估压力袜在预防和治疗PTS中的最佳使用方法。此外，应寻找和评估治疗PTS的新疗法。
