Popescu I, Serbănescu M, Ivăşchescu C
Department of Surgery, Fundeni Clinical Hospital, Bucharest.
Zentralbl Chir. 1991;116(5):327-36.
During a period of 29 years (1960-1989), 19 patients with benign (15 cases) or malignant (4 cases) phylloides tumours were seen at the Surgical Clinic of Fundeni Hospital. Fourteen patients were followed up for a period of 2 to 21 years (mean 9.3 years). Two patients with benign tumours developed malignant recurrences. The malignant potential could not be predicted by histologic criteria. Although 4 patients had malignant tumours and other 2 developed malignant recurrences later, no distant metastases and no death in the 14 patients available for follow up were observed. We believe that in large or malignant tumours simple mastectomy is the surgical treatment of choice, in most benign phylloides tumours a conservative approach (quadrantectomy or lumpectomy) may be considered of the patients can be adaquately followed up.
在29年期间（1960 - 1989年），弗德尼医院外科诊所共收治了19例良性（15例）或恶性（4例）叶状肿瘤患者。14例患者接受了2至21年的随访（平均9.3年）。2例良性肿瘤患者出现了恶性复发。组织学标准无法预测恶性潜能。尽管有4例患者患有恶性肿瘤，另外2例后来出现了恶性复发，但在可供随访的14例患者中未观察到远处转移和死亡情况。我们认为，对于大的或恶性肿瘤，单纯乳房切除术是首选的手术治疗方法；对于大多数良性叶状肿瘤，如果能对患者进行充分随访，则可考虑采用保守治疗方法（象限切除术或肿块切除术）。
