Skoromets A A, Ermolenko I N, Barbas I M, Dozortsev D I, Klimova T T, Kozlova I G, Korenko L A, Morozova A A, Totolian N A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(2):23-6.
Analysis is made of the efficacy of the treatment of CSF hypertension in 40 patients in the phase of exacerbation of multiple sclerosis. Use was made of sorption detoxication methods: hemoperfusion (the author's certificate No.1466754) and enterosorption (the priority certificate No.4465054/14 (115542) dated July 22, 1988). SKH-IK and SKH-2K sorbents were employed as hemoperfusion, using the venovenous scheme of perfusion, the volumetric rate of the blood flow being 100-120 ml/min during 2-3 hours. Altogether 2-3 sessions were carried out, with an interval of 5 to 7 days. For enterosorption, use was made of a crumbled up filamentous carbonic sorbent in a dose of 50-60 mg per kg bw 3 times a day for 20 days in 2 hourly intervals between food intake. Regression of the neurological symptoms began 2-3 hours after the first session of hemoperfusion and 5-6 days after the beginning of the intake of the filamentous carbonic sorbent, increasing throughout the whole treatment course. That coincided with the disappearance of CSF hypertension and normalization of the immunological spectrum of the blood serum. Sorption detoxication brought about no complications and is a method of choice in the treatment of CSF hypertension in patients in the phase of multiple sclerosis exacerbation.
对40例处于多发性硬化症加重期患者的脑脊液高压治疗效果进行了分析。采用了吸附解毒方法：血液灌流（作者证书编号1466754）和肠吸附（1988年7月22日的优先证书编号4465054/14(115542)）。使用SKH-IK和SKH-2K吸附剂进行血液灌流，采用静脉-静脉灌注方案，血流体积速率在2至3小时内为100 - 120毫升/分钟。总共进行2至3次治疗，间隔5至7天。对于肠吸附，使用粉碎的丝状碳吸附剂，剂量为每千克体重50 - 60毫克，每天3次，在进食间隔2小时服用，共20天。血液灌流第一次治疗后2至3小时以及丝状碳吸附剂开始服用后5至6天，神经症状开始消退，且在整个治疗过程中持续改善。这与脑脊液高压的消失以及血清免疫谱的正常化相吻合。吸附解毒未引发并发症，是治疗多发性硬化症加重期患者脑脊液高压的首选方法。
