Calzado Leticia, Galera Carmen María, Arrue Itziar, Rodríguez-Peralto José L, López Sara, Guerra Aurora, Vanaclocha Francisco
Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, Spain.
Actas Dermosifiliogr. 2005 Jul-Aug;96(6):379-81. doi: 10.1016/s0001-7310(05)73095-7.
There are dermatological symptoms in up to 25% of patients with sarcoidosis, and the appearance of specific subcutaneous nodules as a manifestation of this entity is rare. They may even predate other manifestations of sarcoidosis. We present the case of a 38-year-old woman with asymptomatic subcutaneous nodules in the limbs, which corresponded to deep sarcoid granulomas in the histological study. She did not present with any extracutaneous indications. The imaging tests performed revealed right paratracheal adenopathies. This led to the diagnosis of sarcoidosis, in both its subcutaneous and pulmonary forms (stage I). Subcutaneous sarcoidosis is probably an underdiagnosed entity, as fewer than 40 cases are reflected in literature. Its value lies in the fact that it may be the first manifestation of extracutaneous or systemic sarcoidosis, which means that this form of sarcoidosis must be considered in the differential diagnosis of subcutaneous nodular lesions; close follow-up of these patients is also necessary.
高达25%的结节病患者有皮肤症状，而作为该疾病表现的特定皮下结节很少见。它们甚至可能早于结节病的其他表现出现。我们报告一例38岁女性，其四肢有无症状皮下结节，组织学检查显示为深部结节病肉芽肿。她没有任何皮肤外表现。所进行的影像学检查显示右气管旁淋巴结肿大。这导致了皮下和肺部结节病（I期）的诊断。皮下结节病可能是一种诊断不足的疾病，因为文献报道的病例少于40例。其价值在于它可能是皮肤外或全身性结节病的首发表现，这意味着在皮下结节性病变的鉴别诊断中必须考虑这种结节病形式；对这些患者进行密切随访也是必要的。
