混合感染在呼吸道腺病毒感染的儿童中很常见。
Mixed infection is common in children with respiratory adenovirus infection.
作者信息
Korppi M, Leinonen M, Mäkelä P H, Launiala K
机构信息
Department of Paediatrics, University Central Hospital, Kuopio, Finland.
出版信息
Acta Paediatr Scand. 1991 Apr;80(4):413-7. doi: 10.1111/j.1651-2227.1991.tb11875.x.
The presence of concomitant viral or bacterial infection was evaluated in 20 patients hospitalized for adenovirus infection of the middle or lower airways by using new serological methods for detection of both antigens and antibodies. Adenovirus infection was identified by measurement of antibodies with complement fixation test or by direct detection of viral antigen in nasopharyngeal aspirates. Mixed infection was present in 11 (55%) of the 20 patients. Viral coinfection was demonstrated in five (25%) and bacterial in nine (45%) patients. Bacterial coinfection was common, 67%, in children with an infection focus, pneumonia or acute otitis media, but rare, 13%, in those without it. Seroconversion to nontypable Haemophilus influenzae was indicated in six children; four of them were infants, four had pneumonia and three acute otitis media. Pneumococcal infection was indicated in two patients with pneumonia, both aged over two years. Chlamydia trachomatis was involved in one case. The results indicate that bacterial coinfection is common in respiratory adenovirus infection affecting lower airways, especially if pneumonia is present.
采用新的抗原和抗体血清学检测方法，对20例因中、下呼吸道腺病毒感染住院的患者是否合并病毒或细菌感染进行了评估。通过补体结合试验检测抗体或直接检测鼻咽抽吸物中的病毒抗原，来确定腺病毒感染。20例患者中有11例（55%）存在混合感染。5例（25%）患者出现病毒合并感染，9例（45%）患者出现细菌合并感染。在有感染灶、肺炎或急性中耳炎的儿童中，细菌合并感染很常见，占67%，而在没有这些情况的儿童中则很少见，占13%。6名儿童出现了对不可分型流感嗜血杆菌的血清转化；其中4名是婴儿，4名患有肺炎，3名患有急性中耳炎。2例肺炎患者出现肺炎球菌感染，均为两岁以上。1例涉及沙眼衣原体感染。结果表明，在影响下呼吸道的呼吸道腺病毒感染中，细菌合并感染很常见，尤其是在存在肺炎的情况下。
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