Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Trends Endocrinol Metab. 2011 Jul;22(7):259-65. doi: 10.1016/j.tem.2011.03.005. Epub 2011 Apr 15.
The discovery of resistin 10 years ago as a fat cell-secreted factor that modulates insulin resistance suggested a link to the current obesity-associated epidemics of diabetes and cardiovascular disease, which are major human health concerns. Although adipocyte-derived resistin is indisputably linked to insulin resistance in rodent models, the relevance of human resistin is complicated because human resistin is secreted by macrophages rather than adipocytes, and because of the descriptive nature of human epidemiology. In this review, we examine the recent and growing evidence that human resistin is an inflammatory biomarker and a potential mediator of diabetes and cardiovascular disease.
10 年前，人们发现抵抗素是一种脂肪细胞分泌的因子，可调节胰岛素抵抗，这表明它与当前肥胖相关的糖尿病和心血管疾病流行有关，而这些疾病是人类健康的主要关注点。尽管脂肪细胞衍生的抵抗素与啮齿动物模型中的胰岛素抵抗有明确的关联，但人类抵抗素的相关性很复杂，因为人类抵抗素是由巨噬细胞而不是脂肪细胞分泌的，而且由于人类流行病学的描述性质。在这篇综述中，我们检查了最近越来越多的证据，表明人类抵抗素是一种炎症生物标志物，也是糖尿病和心血管疾病的潜在介质。
