Spieker C, Zidek W, Rahn K H
Medizinische Universitäts-Poliklinik, Münster, Germany.
Am J Hypertens. 1991 Apr;4(4 Pt 1):309-14. doi: 10.1093/ajh/4.4.309.
A crucial role of humoral factors in the pathogenesis of primary hypertension is discussed. In 1982 Hamlyn et al demonstrated the presence of a Na+, K(+)-ATPase inhibitor in the plasma of essential hypertensives and showed a significant correlation of the Na+, K(+)-ATPase inhibition with the blood pressure. In this study we examined whether an Na+, K(+)-ATPase inhibitor could be found in the blood of essential hypertensives as compared to patients with secondary hypertension (renal hypertension, renal artery stenosis, pheochromocytoma). Second, the possible correlation between an inhibition of Na+, K(+)-ATPase and the intracellular electrolyte composition was examined. The results demonstrate a similar reduction of Na+, K(+)-ATPase inhibition in both essential hypertensives and secondary hypertensives as compared to normotensive controls. Further, the intracellular electrolyte composition (Na+, Na; K+, Ca) does not show a significant correlation to the degree of Na+, K(+)-ATPase inhibition, whereas a significant correlation between the degree of Na+, K(+)-ATPase inhibition and intracellular Cl- concentration could be demonstrated. The present study shows that an endogenous Na+, K(+)-ATPase inhibitor is also present in secondary forms of hypertension, thus implying that a specific role in the pathogenesis of primary hypertension for an Na+, K(+)-inhibitor is unlikely.
本文讨论了体液因素在原发性高血压发病机制中的关键作用。1982年，哈姆林等人在原发性高血压患者的血浆中发现了一种钠钾ATP酶抑制剂，并表明钠钾ATP酶抑制作用与血压之间存在显著相关性。在本研究中，我们比较了原发性高血压患者与继发性高血压患者（肾性高血压、肾动脉狭窄、嗜铬细胞瘤）血液中是否存在钠钾ATP酶抑制剂。其次，研究了钠钾ATP酶抑制与细胞内电解质组成之间的可能相关性。结果表明，与血压正常的对照组相比，原发性高血压患者和继发性高血压患者的钠钾ATP酶抑制作用均有类似程度的降低。此外，细胞内电解质组成（钠、钠；钾、钙）与钠钾ATP酶抑制程度无显著相关性，而钠钾ATP酶抑制程度与细胞内氯离子浓度之间存在显著相关性。本研究表明，内源性钠钾ATP酶抑制剂也存在于继发性高血压中，因此，钠钾抑制剂在原发性高血压发病机制中不太可能起特定作用。
