Boschi S, Borghi C, Costa F V, Ambrosioni E
Clin Exp Hypertens A. 1985;7(5-6):735-53. doi: 10.3109/10641968509077224.
The ability of plasma extracts to inhibit Na+-K+ ATPase in vitro (P.I.A.) was tested in 20 normotensives, 10 without (F-) and 10 with (F+) familial hypertension, in 20 borderlines (BL) and in 21 essential hypertensives (EH). In these subjects we also measured intralymphocytic sodium (ILSC) and potassium (ILKC) content, P.R.A. urinary aldosterone and Na+(Na+u), and blood pressure. P.I.A. of EH, BL and F+ subjects was significantly higher than that of F-. 60% of EH and BL and 40% of F+ had P.I.A. values greater than the highest found in F-. P.I.A. was significantly related to mean blood pressure (r = 0.63), to ILSC (r = 0.56), to ILKC (r = -0.56), to ILSC/ILKC ratio (r = 0.71) and to Na+u (r = 0.39) but not to P.R.A. or aldosterone. These data demonstrate that plasma extracts from young subjects prone to hypertension may inhibit sodium pump and that this inhibitor may affect blood pressure by altering the Na+/K+ intracellular ratio.
在20名血压正常者（其中10名无家族性高血压，F -；10名有家族性高血压，F +）、2名临界高血压患者（BL）和21名原发性高血压患者（EH）中，测试了血浆提取物在体外抑制钠钾ATP酶的能力（P.I.A.）。在这些受试者中，我们还测量了淋巴细胞内钠（ILSC）和钾（ILKC）含量、肾素活性（P.R.A.）、尿醛固酮和尿钠（Na + u）以及血压。EH、BL和F +受试者的P.I.A.显著高于F -受试者。60%的EH和BL受试者以及40%的F +受试者的P.I.A.值高于F -受试者中的最高值。P.I.A.与平均血压（r = 0.63）、ILSC（r = 0.56）、ILKC（r = -0.56）、ILSC/ILKC比值（r = 0.71）和Na + u（r = 0.39）显著相关，但与P.R.A.或醛固酮无关。这些数据表明，易患高血压的年轻受试者的血浆提取物可能抑制钠泵，并且这种抑制剂可能通过改变细胞内Na + /K +比值来影响血压。
