MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes.

作者信息

Miyake Yoko, Togashi Humika, Tashiro Mitsuru, Yamaguchi Hiroshi, Oda Shuji, Kudo Megumi, Tanaka Yoshiyuki, Kondo Yoshinori, Sawa Ryuichi, Fujimoto Takashi, Machinami Tomoya, Ono Akira

机构信息

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Minami-ohsawa 1-1, Hachioji, Tokyo 192-0397 Japan.

出版信息

J Am Chem Soc. 2006 Feb 22;128(7):2172-3. doi: 10.1021/ja056354d.

DOI:10.1021/ja056354d

PMID:16478145

Abstract

The very specific binding of the HgII ion unexpectedly and significantly stabilizes naturally occurring thymine-thymine base mispairing in DNA duplexes. Following this finding, we prepared DNA duplexes containing metal-mediated base pairs at the desired sites, as well as novel double helical architectures consisting only of thymine-HgII-thymine pairs.

摘要