[柬埔寨龙血树抗肿瘤新用途的研究]
[Study on the new use of antitumor of Dracaena cambodiana].
作者信息
Mei Wenli, Dai Haofu, Wu Jiao, Zhuang Ling, Hong Kui
机构信息
State Key Laboratory of Tropical Crops Biotechnology, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101.
出版信息
Zhong Yao Cai. 2005 Oct;28(10):871-3.
OBJECTIVE
To screen the antitumor extract from Dracaena cambodiana Pierre ex Gagnep.
METHODS
The 95% ehanol extract from Dracaena cambodiana was treated in the way of solvent partition and resin column chromatography to afford different extracts. The antitumor activities of the different extracts in vitro were determined by MTT assay.
RESULTS
The chloroform extract, ethyl acetate extract, and n-butanol extract showed strong growth inhibitory on B16 cells and SMMC-721 cells,and the extract of methanol elute showed weak activity,whereas the extracts of water,water elution,and 50% methanol/H2O elution had no activity. The chloroform extract was the most active.
CONCLUSION
The chloroform extract is the principal antitumor extract from Dracaena cambodiana.
目的
筛选柬埔寨龙血树的抗肿瘤提取物。
方法
对柬埔寨龙血树的95%乙醇提取物进行溶剂萃取和树脂柱色谱分离，得到不同提取物。采用MTT法测定不同提取物的体外抗肿瘤活性。
结果
氯仿提取物、乙酸乙酯提取物和正丁醇提取物对B16细胞和SMMC - 721细胞具有较强的生长抑制作用，甲醇洗脱物提取物活性较弱，而水提取物、水洗脱物和50%甲醇/水洗脱物无活性。氯仿提取物活性最强。
结论
氯仿提取物是柬埔寨龙血树的主要抗肿瘤提取物。
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