柬埔寨龙血树中不同寻常的22S-螺旋甾烷甾体化合物。
Unusual 22S-spirostane steroids from Dracaena cambodiana.
作者信息
Minh Chau Van, Dat Nguyen Tien, Dang Nguyen Hai, Nam Nguyen Hoai, Ban Ninh Khac, Tuyen Nguyen Van, Huong Le Mai, Huong Tran Thu, Kiem Phan Van
机构信息
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
出版信息
Nat Prod Commun. 2009 Sep;4(9):1197-200.
From the methanol extract of Dracaena cambodiana roots two unusual 22S-spirostane steroids (1beta,3beta,14alpha,20R,22S,25R)-spirost-5-ene-1,3,14-triol (1) and (lbeta,3beta,14alpha,15alpha,20R,22S,25R)-spirost-5-ene-tetrol (2) have been isolated, together with a known 22R-spirostane compound, namogenin B (3). Their structures were elucidated by spectroscopic and spectrometric methods, including HRMS and extensive 1D and 2D NMR spectroscopy. Compound 1 showed significant antimicrobial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Fusarium oxysporum, with MIC values of 45.0, 25.0 and 50.0 microg/mL, respectively.
从柬埔寨龙血树根部的甲醇提取物中分离出两种不寻常的22S-螺旋甾烷类固醇，即(1β,3β,14α,20R,22S,25R)-螺旋甾-5-烯-1,3,14-三醇（1）和(1β,3β,14α,15α,20R,22S,25R)-螺旋甾-5-烯四醇（2），以及一种已知的22R-螺旋甾烷化合物那摩皂苷元B（3）。通过光谱和质谱方法，包括高分辨质谱（HRMS）以及广泛的一维和二维核磁共振光谱（NMR）对它们的结构进行了阐明。化合物1对铜绿假单胞菌、金黄色葡萄球菌和尖孢镰刀菌显示出显著的抗菌活性，其最低抑菌浓度（MIC）值分别为45.0、25.0和50.0微克/毫升。
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