Schubert David, Dargusch Richard, Raitano Joan, Chan Siu-Wai
The Salk Institute, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
Biochem Biophys Res Commun. 2006 Mar 31;342(1):86-91. doi: 10.1016/j.bbrc.2006.01.129. Epub 2006 Feb 3.
The responses of cells exposed to nanoparticles have been studied with regard to toxicity, but very little attention has been paid to the possibility that some types of particles can protect cells from various forms of lethal stress. It is shown here that nanoparticles composed of cerium oxide or yttrium oxide protect nerve cells from oxidative stress and that the neuroprotection is independent of particle size. The ceria and yttria nanoparticles act as direct antioxidants to limit the amount of reactive oxygen species required to kill the cells. It follows that this group of nanoparticles could be used to modulate oxidative stress in biological systems.
关于暴露于纳米颗粒的细胞的反应，已针对毒性进行了研究，但对于某些类型的颗粒可以保护细胞免受各种形式的致死性应激这一可能性，关注甚少。本文表明，由氧化铈或氧化钇组成的纳米颗粒可保护神经细胞免受氧化应激，并且这种神经保护作用与颗粒大小无关。氧化铈和氧化钇纳米颗粒作为直接抗氧化剂，可限制杀死细胞所需的活性氧的量。因此，这组纳米颗粒可用于调节生物系统中的氧化应激。
