Rolain Jean-Marc, Lambert Frédéric, Raoult Didier
Unité des rickettsies, CNRS UMR 6020, Université de la Méditerranée, Faculté de medicine, 13385 Marseille cedex 5, France.
Ann N Y Acad Sci. 2005 Dec;1063:252-6. doi: 10.1196/annals.1355.039.
In this study we have evaluated the in vitro activity of antibiotics against 13 new isolates of Coxiella burnetii using a real-time quantitative PCR assay. MICs against doxycycline ranged from 1 to 8 microg/mL, telithromycin from 0.5 to 2 microg/mL, and all strains had MICs > or = 8 microg/mL for erythromycin. We report that strains resistant to doxycycline exist either in humans or animals.
在本研究中，我们使用实时定量PCR检测法评估了抗生素对13株新分离的伯氏考克斯体的体外活性。多西环素的最低抑菌浓度（MIC）范围为1至8微克/毫升，泰利霉素为0.5至2微克/毫升，所有菌株对红霉素的MIC均≥8微克/毫升。我们报告称，对多西环素耐药的菌株存在于人类或动物中。
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