贝氏考克斯体：神秘的国际病原体。
Coxiella burnetii: international pathogen of mystery.
机构信息
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
出版信息
Microbes Infect. 2020 Apr;22(3):100-110. doi: 10.1016/j.micinf.2019.09.001. Epub 2019 Sep 28.
Abstract
Coxiella burnetii is an intracellular bacterium that causes acute and chronic Q fever. This unique pathogen has been historically challenging to study due to obstacles in genetically manipulating the organism and the inability of small animal models to fully mimic human Q fever. Here, we review the current state of C. burnetii research, highlighting new approaches that allow the mechanistic study of infection in disease relevant settings.
摘要
贝氏柯克斯体是一种细胞内细菌，可引起急性和慢性 Q 热。由于在遗传操作该生物体方面存在障碍以及小型动物模型无法完全模拟人类 Q 热，这种独特的病原体在历史上一直具有挑战性。在这里，我们回顾了目前对 C. 燃烧的研究状态。贝氏柯克斯体，突出了允许在与疾病相关的环境中进行感染机制研究的新方法。
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本文引用的文献
1
The Discovery of Q Fever and Its Cause.
Am J Med Sci. 2019 Jul;358(1):3-10. doi: 10.1016/j.amjms.2019.04.006. Epub 2019 Apr 12.
2
Characterization of Early Stages of Human Alveolar Infection by the Q Fever Agent .
Infect Immun. 2019 Apr 23;87(5). doi: 10.1128/IAI.00028-19. Print 2019 Mar.
3
Comparative virulence of diverse Coxiella burnetii strains.
Virulence. 2019 Dec;10(1):133-150. doi: 10.1080/21505594.2019.1575715.
4
The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole.
PLoS One. 2019 Feb 14;14(2):e0212202. doi: 10.1371/journal.pone.0212202. eCollection 2019.
5
Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole.
mBio. 2019 Feb 5;10(1):e02816-18. doi: 10.1128/mBio.02816-18.
6
Interaction between autophagic vesicles and the Coxiella-containing vacuole requires CLTC (clathrin heavy chain).
Autophagy. 2018;14(10):1710-1725. doi: 10.1080/15548627.2018.1483806. Epub 2018 Jul 29.
7
Coxiella burnetii: A Hidden Pathogen in Interstitial Lung Disease?
Clin Infect Dis. 2018 Sep 14;67(7):1120-1124. doi: 10.1093/cid/ciy278.
8
Coxiella burnetii Subverts p62/Sequestosome 1 and Activates Nrf2 Signaling in Human Macrophages.
Infect Immun. 2018 Apr 23;86(5). doi: 10.1128/IAI.00608-17. Print 2018 May.
9
Genetic mechanisms of Coxiella burnetii lipopolysaccharide phase variation.
PLoS Pathog. 2018 Feb 26;14(3):e1006922. doi: 10.1371/journal.ppat.1006922. eCollection 2018 Mar.
10
Detection of Coxiella burnetii in heart valve sections by fluorescence in situ hybridization.
J Med Microbiol. 2018 Apr;67(4):537-542. doi: 10.1099/jmm.0.000704. Epub 2018 Feb 20.
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