Ochs-Balcom H M, Grant B J B, Muti P, Sempos C T, Freudenheim J L, Browne R W, McCann S E, Trevisan M, Cassano P A, Iacoviello L, Schünemann H J
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Eur J Clin Nutr. 2006 Aug;60(8):991-9. doi: 10.1038/sj.ejcn.1602410. Epub 2006 Feb 15.
The objective of this study was to investigate the association between antioxidant nutrients and markers of oxidative stress with pulmonary function in persons with chronic airflow limitation.
Cross-sectional study exploring the association of antioxidant nutrients and markers of oxidative stress with forced expiratory volume in the first second (FEV1%) and forced vital capacity (FVC%).
SETTING/SUBJECTS: The study data included 218 persons with chronic airflow limitation recruited randomly from the general population of Erie and Niagara counties, New York State, USA.
After adjustment for covariates, multiple linear regression analysis showed that serum beta-cryptoxanthin, lutein/zeaxanthin, and retinol, and dietary beta-carotene, beta-cryptoxanthin, lutein/zeaxanthin, vitamin C, and lycopene were positively associated with FEV1% (P < 0.05, all associations). Serum vitamins beta-cryptoxanthin, lutein/zeaxanthin, and lycopene, and dietary beta-cryptoxanthin, beta-carotene, vitamin C, and lutein/zeaxanthin were positively associated with FVC% (P < 0.05, all associations). Erythrocytic glutathione was negatively associated with FEV1%, while plasma thiobarbituric acid-reactive substances (TBARS) were negatively associated with FVC% (P < 0.05).
These results support the hypothesis that an imbalance in antioxidant/oxidant status is associated with chronic airflow limitation, and that dietary habits and/or oxidative stress play contributing roles.
本研究的目的是调查抗氧化营养素和氧化应激标志物与慢性气流受限患者肺功能之间的关联。
横断面研究，探讨抗氧化营养素和氧化应激标志物与第一秒用力呼气量（FEV1%）和用力肺活量（FVC%）之间的关联。
设置/研究对象：研究数据包括从美国纽约州伊利县和尼亚加拉县普通人群中随机招募的218名慢性气流受限患者。
在对协变量进行调整后，多元线性回归分析显示，血清β-隐黄质、叶黄素/玉米黄质和视黄醇，以及膳食β-胡萝卜素、β-隐黄质、叶黄素/玉米黄质、维生素C和番茄红素与FEV1%呈正相关（所有关联，P<0.05）。血清维生素β-隐黄质、叶黄素/玉米黄质和番茄红素，以及膳食β-隐黄质、β-胡萝卜素、维生素C和叶黄素/玉米黄质与FVC%呈正相关（所有关联，P<0.05）。红细胞谷胱甘肽与FEV1%呈负相关，而血浆硫代巴比妥酸反应性物质（TBARS）与FVC%呈负相关（P<0.05）。
这些结果支持以下假设，即抗氧化/氧化状态失衡与慢性气流受限有关，并且饮食习惯和/或氧化应激起了促进作用。
