Melo van Lent Debora, Leermakers Elisabeth T M, Hofman Albert, Stricker Bruno H, Brusselle Guy G, Franco Oscar H, Lahousse Lies, Kiefte-de Jong Jessica C
1Department of Epidemiology,Erasmus MC University Medical Center,3000 CA, Rotterdam,The Netherlands.
Br J Nutr. 2017 Mar;117(5):720-730. doi: 10.1017/S0007114517000319. Epub 2017 Apr 5.
Lutein, a fat-soluble carotenoid with antioxidant properties, may have an effect on respiratory health. However, the evidence is inconsistent. We aimed to cross-sectionally investigate the association between lutein intake and lung function by measuring forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC% in adults (aged 45-79 years). We included 4402 participants from the Rotterdam Study, a prospective cohort study in The Netherlands. Lutein intake was assessed using a validated FFQ. Lung function was assessed using spirometry around the same time point as the dietary assessment. No independent association was found between lutein intake and FEV1 (-12·17 (95 % CI -34·21, 9·87) ml per sd increase in lutein) after adjustment for age, sex, height, cohort effect, ethnicity, education, weight, total daily energy intake, smoking status, physical activity, and intakes of fatty acids, dietary fibre, alcohol, β-carotene, β-crypotoxanthin, lycopene and zeaxanthin. There was also no association between lutein and FVC or FEV1/FVC%. However, after stratification by smoking status, lutein intake was significantly associated with lower FEV1/FVC% in current smokers (-1·69 (95 % CI -2·93, -0·45) % per sd increase of lutein) independent of other carotenoids. The present study does not support an independent association between lutein intake and lung function in adults. However, future studies should focus on the potential inverse association between high lutein intake and lung function in specific risk groups such as smokers.
叶黄素是一种具有抗氧化特性的脂溶性类胡萝卜素，可能对呼吸健康有影响。然而，证据并不一致。我们旨在通过测量成年人（45 - 79岁）的1秒用力呼气量（FEV1）、用力肺活量（FVC）和FEV1/FVC%，横断面研究叶黄素摄入量与肺功能之间的关联。我们纳入了来自荷兰一项前瞻性队列研究——鹿特丹研究的4402名参与者。使用经过验证的食物频率问卷评估叶黄素摄入量。在与饮食评估大致相同的时间点，使用肺活量测定法评估肺功能。在调整年龄、性别、身高、队列效应、种族、教育程度、体重、每日总能量摄入量、吸烟状况、身体活动以及脂肪酸、膳食纤维、酒精、β - 胡萝卜素、β - 隐黄质、番茄红素和玉米黄质的摄入量后，未发现叶黄素摄入量与FEV1之间存在独立关联（叶黄素每标准差增加量，FEV1变化为 - 12.17（95%CI - 34.21，9.87）ml）。叶黄素与FVC或FEV1/FVC%之间也没有关联。然而，按吸烟状况分层后，与其他类胡萝卜素无关，当前吸烟者的叶黄素摄入量与较低的FEV1/FVC%显著相关（叶黄素每标准差增加量，FEV1/FVC%变化为 - 1.69（95%CI - 2.93， - 0.45）%）。本研究不支持成年人叶黄素摄入量与肺功能之间存在独立关联。然而，未来的研究应关注高叶黄素摄入量与特定风险人群（如吸烟者）肺功能之间潜在的负相关关系。
