Hu Dan, Xu Xiaojuan, Gonzalez-Lima Francisco
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, 02139, USA.
Int J Neurosci. 2006 Mar;116(3):265-80. doi: 10.1080/00207450500403108.
The present study investigated whether more vicarious trial-and-error (VTE) behavior, defined by head movement from one stimulus to another at a choice point during simultaneous discriminations, led to better visual discrimination learning in a Y-maze, and whether VTE behavior was a function of the hippocampus by measuring regional brain cytochrome oxidase (C.O.) activity, an index of neuronal metabolic activity. The results showed that the more VTEs a rat made, the better the rat learned the visual discrimination. Furthermore, both learning and VTE behavior during learning were correlated to C.O. activity in the hippocampus, suggesting that the hippocampus plays a role in VTE behavior during discrimination learning.
本研究调查了在同时进行辨别时，由在选择点从一个刺激物向另一个刺激物的头部移动所定义的更多替代性试错（VTE）行为，是否会导致在Y迷宫中更好的视觉辨别学习，以及VTE行为是否通过测量区域脑细胞色素氧化酶（C.O.）活性（一种神经元代谢活动指标）而成为海马体的一种功能。结果表明，大鼠做出的VTE越多，其视觉辨别学习得就越好。此外，学习期间的学习和VTE行为均与海马体中的C.O.活性相关，这表明海马体在辨别学习期间的VTE行为中发挥作用。
