原子弹辐射暴露与动脉粥样硬化患病率的关系：原子弹爆炸幸存者辐射效应研究基金会成人健康研究
Prevalence of atherosclerosis in relation to atomic bomb radiation exposure: an RERF Adult Health Study.
作者信息
Yamada Michiko, Naito Kumiko, Kasagi Fumiyoshi, Masunari Naomi, Suzuki Gen
机构信息
Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan.
出版信息
Int J Radiat Biol. 2005 Nov;81(11):821-6. doi: 10.1080/09553000600555504.
PURPOSE
To determine whether exposure to atomic bomb radiation altered the prevalence of asymptomatic atherosclerosis.
MATERIAL AND METHODS
In a cross-sectional analysis, we examined aortic arch calcification by plain chest radiography and common carotid artery intima-media thickness (IMT) by ultrasonography among 1804 survivors of the atomic bombing in Hiroshima. We evaluated the association between atherosclerotic changes and radiation exposure, while adjusting for potentially confounding factors.
RESULTS
Multivariate logistic regression analysis showed that aortic arch calcification was significantly associated with radiation exposure (p < 0.05). The odds ratio at 1 Gy was 1.30 (95% confidence interval [CI]: 1.05 - 1.53) for men and 1.31 (95% CI: 1.13 - 1.51) for women. Carotid artery IMT did not vary significantly with radiation dose (p = 0.18).
CONCLUSION
Radiation dose contributed to the prevalence of aortic atherosclerosis but not carotid artery atherosclerosis in atomic bomb survivors.
目的
确定暴露于原子弹辐射是否改变了无症状动脉粥样硬化的患病率。
材料与方法
在一项横断面分析中，我们通过胸部X线平片检查了广岛原子弹爆炸1804名幸存者的主动脉弓钙化情况，并通过超声检查了颈总动脉内膜中层厚度（IMT）。我们评估了动脉粥样硬化变化与辐射暴露之间的关联，同时对潜在的混杂因素进行了校正。
结果
多因素逻辑回归分析显示，主动脉弓钙化与辐射暴露显著相关（p<0.05）。男性1 Gy时的比值比为1.30（95%置信区间[CI]：1.05 - 1.53），女性为1.31（95%CI：1.13 - 1.51）。颈动脉IMT随辐射剂量无显著变化（p = 0.18）。
结论
在原子弹爆炸幸存者中，辐射剂量导致了主动脉粥样硬化的患病率增加，但未导致颈动脉粥样硬化患病率增加。
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