Allen N, Mendell J R, Billmaier D J, Fontaine R E, O'Neill J
Arch Neurol. 1975 Apr;32(4):209-18. doi: 10.1001/archneur.1975.00490460025001.
Cases of toxic distal polyneuropathy have been studied in a plant producing plastic-coated and color-printed fabrics. After the screenig of 1,157 employees, a total of 86 verified cases were detected. Of these, 11 were moderate to severe in intensity and usually with motor and sensory involvement; 38 were mild, with sensory signs prevailing; and 37 were minimal, but with characteristic electro-diagnostic abnormalities. Muscle weakness and electromyographic abnormalities were predominantly distal. Reflex loss was minimal. Sensory deficits were distal and limited to pain, touch, and temperature discrimination with occasional loss of vibration sense. The distribution of involvement severity of the disorder, and temporal course of the outbreak correlated with exposure with methyl n-butyl ketone. After elimination of this agent improvement was noted in the majority of cases.
在一家生产塑料涂层和彩色印花织物的工厂对中毒性远端多发性神经病病例进行了研究。在对1157名员工进行筛查后，共检测出86例确诊病例。其中，11例症状为中度至重度，通常伴有运动和感觉障碍；38例症状较轻，以感觉症状为主；37例症状轻微，但有特征性的电诊断异常。肌无力和肌电图异常主要出现在远端。反射减弱不明显。感觉缺陷位于远端，仅限于疼痛、触觉和温度辨别，偶尔会出现振动觉丧失。该疾病受累严重程度的分布以及疫情的时间进程与甲基正丁基酮暴露相关。在消除该制剂后，大多数病例病情有所改善。
