Jones H B, Cavanagh J B
Acta Neuropathol. 1982;58(4):286-90. doi: 10.1007/BF00688611.
Rats were given 2,5-hexanediol, a metabolite of n-hexane, in the drinking water until they developed a marked degree of paresis over about 7 weeks and were then allowed to recover naturally. The time course and the manner of removal of the neurofilamentous masses accumulated within axons caused by the intoxication were followed by electron microscopy over the subsequent 8 weeks. The neurofilamentous masses slowly disappeared completely from the axons of this tract, without there being any degeneration, over 6-7 weeks. They disappeared first from the fibres in the brachium of the superior colliculus, perhaps by transport towards the terminals, and later from the axons within the superior colliculus itself. Particularly in preterminal fibres in the superior colliculus the filamentous accumulations became permeated by a network of smooth endoplasmic reticulum which may have played a part in the removal of the filaments. Accumulations of mitochondria and dense bodies in preterminal regions, presumed to be caused by obstruction to retrograde transport, disappeared pari passu with loss of the filaments. The significance of these events in relation to neurofilament metabolism is discussed.
给大鼠饮用含有正己烷代谢物2,5 -己二醇的水，持续约7周，直至它们出现明显程度的轻瘫，然后让它们自然恢复。在随后的8周内，通过电子显微镜观察中毒引起的轴突内积累的神经丝团块的清除时间进程和方式。在6 - 7周内，这些神经丝团块从该束的轴突中缓慢完全消失，且没有任何退化现象。它们首先从上丘臂的纤维中消失，可能是通过向终末运输，随后从上丘本身的轴突中消失。特别是在上丘的终末前纤维中，丝状聚集体被光滑内质网网络渗透，这可能在细丝的清除中起了作用。终末前区域线粒体和致密体的积累，推测是由逆行运输受阻引起的，随着细丝的消失而同步消失。讨论了这些事件与神经丝代谢的关系。
