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激光等离子体加速器放疗:实验性准单能电子束沉积剂量的蒙特卡罗模拟

Radiotherapy with laser-plasma accelerators: Monte Carlo simulation of dose deposited by an experimental quasimonoenergetic electron beam.

作者信息

Glinec Y, Faure J, Malka V, Fuchs T, Szymanowski H, Oelfke U

机构信息

Laboratoire d'Optique Appliquée-ENSTA, UMR 7639, CNRS, Ecole Polytechnique, 91761 Palaiseau, France.

出版信息

Med Phys. 2006 Jan;33(1):155-62. doi: 10.1118/1.2140115.

Abstract

The most recent experimental results obtained with laser-plasma accelerators are applied to radio-therapy simulations. The narrow electron beam, produced during the interaction of the laser with the gas jet, has a high charge (0.5 nC) and is quasimonoenergetic (170 +/- 20 MeV). The dose deposition is calculated in a water phantom placed at different distances from the diverging electron source. We show that, using magnetic fields to refocus the electron beam inside the water phantom, the transverse penumbra is improved. This electron beam is well suited for delivering a high dose peaked on the propagation axis, a sharp and narrow tranverse penumbra combined with a deep penetration.

摘要

最近用激光等离子体加速器获得的实验结果被应用于放射治疗模拟。在激光与气体射流相互作用过程中产生的窄电子束,具有高电荷量(0.5纳库)且是准单能的(170±20兆电子伏)。在放置于距发散电子源不同距离处的水模体中计算剂量沉积。我们表明,利用磁场在水模体内对电子束进行再聚焦,横向半影得到了改善。这种电子束非常适合在传播轴上提供高剂量峰值,具有尖锐且狭窄的横向半影以及深穿透能力。

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