SUPA, Department of Physics, University of Strathclyde, G4 0NG, Glasgow, UK.
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, G4 0RE, Glasgow, UK.
Sci Rep. 2019 Jul 25;9(1):10837. doi: 10.1038/s41598-019-46630-w.
The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.
由于相对论效应，超高能电子（VHEE）的惯性增加，减少了散射，并能够辐照深部肿瘤。然而，对于准直或发散光束，入射剂量和出射剂量都很高。在这里，我们基于水模中聚焦 VHEE 束的蒙特卡罗模拟进行了一项研究，结果表明，剂量可以集中到一个小的、定义明确的体积单元中，该单元可以成形或扫描以治疗深部肿瘤。周围组织的剂量分布在更大的体积中，与准直束相比，单个光束的峰值表面和出射剂量降低了一个数量级以上。
