Van der Poel Wim H M, Van der Heide Reina, Verstraten Elisabeth R A M, Takumi Katsuhisa, Lina Peter H C, Kramps Johannes A
National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Emerg Infect Dis. 2005 Dec;11(12):1854-9. doi: 10.3201/eid1112.041200.
To study European bat lyssavirus (EBLV) in bat reservoirs in the Netherlands, native bats have been tested for rabies since 1984. For all collected bats, data including species, age, sex, and date and location found were recorded. A total of 1,219 serotine bats, Eptesicus serotinus, were tested, and 251 (21%) were positive for lyssavirus antigen. Five (4%) of 129 specimens from the pond bat, Myotis dasycneme, were positive. Recently detected EBLV RNA segments encoding the nucleoprotein were sequenced and analyzed phylogenetically (45 specimens). All recent serotine bat specimens clustered with genotype 5 (EBLV1) sequences, and homologies within subgenotypes EBLV1a and EBLV1b were 99.0%-100% and 99.2%-100%, respectively. Our findings indicate that EBLVs of genotype 5 are endemic in the serotine bat in the Netherlands. Since EBLVs can cause fatal infections in humans, all serotine and pond bats involved in contact incidents should be tested to determine whether the victim was exposed to EBLVs.
为了研究荷兰蝙蝠宿主中的欧洲蝙蝠狂犬病病毒（EBLV），自1984年以来对当地蝙蝠进行了狂犬病检测。对于所有采集的蝙蝠，记录了包括物种、年龄、性别以及发现日期和地点等数据。总共检测了1219只普通伏翼蝙蝠（Eptesicus serotinus），其中251只（21%）狂犬病病毒抗原呈阳性。从水鼠耳蝠（Myotis dasycneme）采集的129个样本中有5个（4%）呈阳性。对最近检测到的编码核蛋白的EBLV RNA片段进行了测序，并进行了系统发育分析（45个样本）。所有最近的普通伏翼蝙蝠样本都与基因型5（EBLV1）序列聚类，EBLV1a和EBLV1b亚基因型内的同源性分别为99.0% - 100%和99.2% - 100%。我们的研究结果表明，基因型5的EBLV在荷兰的普通伏翼蝙蝠中呈地方性流行。由于EBLV可导致人类致命感染，所有涉及接触事件的普通伏翼蝙蝠和水鼠耳蝠都应进行检测，以确定受害者是否接触过EBLV。
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