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光动力疗法大面积治疗痣样基底细胞癌综合征患者的多发性基底细胞癌

Broad area photodynamic therapy for treatment of multiple basal cell carcinomas in a patient with nevoid basal cell carcinoma syndrome.

作者信息

Chapas Anne M, Gilchrest Barbara A

机构信息

Laser & Skin Surgery Center of New York, New York, NY 10016, USA.

出版信息

J Drugs Dermatol. 2006 Feb;5(2 Suppl):3-5.

PMID:16485873
Abstract

We report a case of a 73-year-old man with nevoid basal cell carcinoma syndrome who was referred to us with multiple basal cell carcinomas on his face and chest. The patient underwent photodynamic therapy utilizing a 1-hour incubation of Levulan Kerastick delta-aminolevulinic acid 20% topical solution applied to the full face and illumination with a BLU-U blue light source (10 J/cm2) every 2 to 3 months for a total of 4 treatments. This treatment strategy resulted in multiple benefits, including reducing the number and size of his existing basal cell carcinomas, improving the appearance of previous surgical scars, and decreasing the rate of tumor development.

摘要

我们报告了一例患有痣样基底细胞癌综合征的73岁男性病例,该患者因面部和胸部出现多处基底细胞癌而前来我院就诊。患者接受了光动力疗法,每2至3个月使用20%的外用溶液Levulan Kerastickδ-氨基酮戊酸全脸涂抹并孵育1小时,然后用BLU-U蓝光光源(10 J/cm²)照射,共进行了4次治疗。这种治疗策略带来了多种益处,包括减少现有基底细胞癌的数量和大小、改善先前手术疤痕的外观以及降低肿瘤发展速度。

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1
Broad area photodynamic therapy for treatment of multiple basal cell carcinomas in a patient with nevoid basal cell carcinoma syndrome.光动力疗法大面积治疗痣样基底细胞癌综合征患者的多发性基底细胞癌
J Drugs Dermatol. 2006 Feb;5(2 Suppl):3-5.
2
delta-Aminolevulinic acid and blue light photodynamic therapy for treatment of multiple basal cell carcinomas in two patients with nevoid basal cell carcinoma syndrome.δ-氨基乙酰丙酸与蓝光光动力疗法治疗两名痣样基底细胞癌综合征患者的多发性基底细胞癌
Dermatol Surg. 2004 Jul;30(7):1054-61. doi: 10.1111/j.1524-4725.2004.30317.x.
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Treatment of diffuse basal cell carcinomas and basaloid follicular hamartomas in nevoid basal cell carcinoma syndrome by wide-area 5-aminolevulinic acid photodynamic therapy.采用大面积5-氨基酮戊酸光动力疗法治疗痣样基底细胞癌综合征中的弥漫性基底细胞癌和基底样毛囊错构瘤。
Arch Dermatol. 2005 Jan;141(1):60-7. doi: 10.1001/archderm.141.1.60.
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Fractionated 5-aminolevulinic acid photodynamic therapy in the treatment of a giant recurrent superficial basal cell carcinoma.分次5-氨基酮戊酸光动力疗法治疗巨大复发性浅表基底细胞癌
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Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma.光动力疗法治疗大面积或多发性鲍恩病和基底细胞癌。
Arch Dermatol. 2001 Mar;137(3):319-24.
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Light fractionation significantly improves the response of superficial basal cell carcinoma to aminolaevulinic acid photodynamic therapy: five-year follow-up of a randomized, prospective trial.轻度分割显著提高浅层基底细胞癌对氨基酮戊酸光动力疗法的反应:一项随机、前瞻性试验的 5 年随访。
Acta Derm Venereol. 2012 Nov;92(6):641-7. doi: 10.2340/00015555-1448.
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Unilateral Basal cell carcinomas: an unusual entity treated with photodynamic therapy.单侧基底细胞癌:一种采用光动力疗法治疗的罕见病症。
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[Photodynamic therapy of nasal basal cell carcinoma].[鼻基底细胞癌的光动力疗法]
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Epidermoid cysts mimicking recurrence of superficial basal cell carcinoma following photodynamic therapy.光动力治疗后酷似浅表基底细胞癌复发的表皮样囊肿
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Topical photodynamic therapy in clinical dermatology.临床皮肤科中的局部光动力疗法。
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引用本文的文献

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Advances in Photodynamic Therapy for the Treatment of Actinic Keratosis and Nonmelanoma Skin Cancer: A Narrative Review.光动力疗法治疗光化性角化病和非黑色素瘤皮肤癌的研究进展:一项叙述性综述
Dermatol Ther (Heidelb). 2023 Mar;13(3):689-716. doi: 10.1007/s13555-023-00888-1. Epub 2023 Jan 20.
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Current evidence and applications of photodynamic therapy in dermatology.光动力疗法在皮肤科的当前证据及应用
Clin Cosmet Investig Dermatol. 2014 May 21;7:145-63. doi: 10.2147/CCID.S35334. eCollection 2014.
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Aminolevulinic Acid-photodynamic therapy of Basal cell carcinoma and factors affecting the response to treatment: a clinical trial.
氨基乙酰丙酸光动力疗法治疗基底细胞癌及影响治疗反应的因素:一项临床试验
Indian J Dermatol. 2013 Jul;58(4):327. doi: 10.4103/0019-5154.113968.
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Photodynamic therapy in the treatment of basal cell carcinoma.光动力疗法治疗基底细胞癌
J Med Life. 2013 Mar 15;6(1):50-4. Epub 2013 Mar 25.
5
Therapeutic and Aesthetic Uses of Photodynamic Therapy Part three of a five-part series: Chemoprevention Utilizing ALA-PDT.光动力疗法的治疗与美学应用 五部分系列文章的第三部分:利用5-氨基酮戊酸光动力疗法进行化学预防
J Clin Aesthet Dermatol. 2008 Nov;1(4):26-32.