Cvetkovski Rikke Skoet, Zachariae Robert, Jensen Henrik, Olsen Jørn, Johansen Jeanne Duus, Agner Tove
Department of Dermatology, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Contact Dermatitis. 2006 Feb;54(2):106-11. doi: 10.1111/j.0105-1873.2006.00783.x.
Occupational hand eczema (OHE) is the most frequently recognized occupational disease in Denmark, and despite governmental attempts to reduce exposure to harmful occupational allergens, the number of new cases has remained almost unchanged since the mid-1990s. Some studies have indicated that OHE has considerable impact on quality of life (QoL) and may lead to depression. The aims of the study were to determine risk factors for low QoL, the frequency and severity of depression among OHE patients and changes in QoL and depression after 12 months of follow up. The study population, 758 patients, comprised all new recognized cases from the Danish National Board of Industrial Injuries Registry between October 2001 and November 2002. All patients received a questionnaire to determine impairment of QoL and depressive symptoms. A similar follow-up questionnaire was posted after 1 year. The response rate was 82% at baseline and 91% at follow up. The mean Dermatology Life Quality Index total score was 5.5 for all patients and 7.8 for severe OHE cases. Severe OHE cases and lower socioeconomic status were independently associated with low QoL. The prevalence of moderate-to-severe depression was 9%. Only minor changes in QoL and depressive symptoms were found after 12 months of follow up.
职业性手部湿疹（OHE）是丹麦最常被确诊的职业病，尽管政府试图减少有害职业过敏原的接触，但自20世纪90年代中期以来，新病例数几乎没有变化。一些研究表明，职业性手部湿疹对生活质量（QoL）有相当大的影响，可能导致抑郁。该研究的目的是确定生活质量低下的风险因素、职业性手部湿疹患者抑郁的频率和严重程度，以及随访12个月后生活质量和抑郁的变化。研究人群包括758名患者，涵盖了2001年10月至2002年11月丹麦国家工伤登记局所有新确诊的病例。所有患者都收到一份问卷，以确定生活质量受损情况和抑郁症状。1年后发放了一份类似的随访问卷。基线时的回复率为82%，随访时为91%。所有患者的皮肤病生活质量指数总分平均为5.5，重度职业性手部湿疹患者为7.8。重度职业性手部湿疹病例和较低的社会经济地位与生活质量低下独立相关。中度至重度抑郁症的患病率为9%。随访12个月后，生活质量和抑郁症状仅有轻微变化。
