Bagg Jeremy, Jackson Margaret S, Petrina Sweeney M, Ramage Gordon, Davies Andrew N
University of Glasgow Dental School, UK.
Oral Oncol. 2006 May;42(5):487-92. doi: 10.1016/j.oraloncology.2005.10.002. Epub 2006 Feb 20.
Yeasts that are resistant to azole antifungal drugs are increasingly isolated from the mouths of cancer patients suffering from oral fungal infections. Tea tree oil is an agent possessing antimicrobial properties that may prove useful in the prevention and management of infections caused by these organisms. In this study, 301 yeasts isolated from the mouths of 199 patients suffering from advanced cancer were examined by an in vitro agar dilution assay for susceptibility to tea tree oil. All of the isolates tested were susceptible, including 41 that were known to be resistant to both fluconazole and itraconazole. Clinical studies of tea tree oil as an agent for the prevention and treatment of oral fungal infections in immunocompromised patients merit consideration.
对唑类抗真菌药物耐药的酵母菌越来越多地从患有口腔真菌感染的癌症患者口腔中分离出来。茶树油是一种具有抗菌特性的药物，可能在预防和治疗这些微生物引起的感染方面有用。在本研究中，通过体外琼脂稀释试验检测了从199例晚期癌症患者口腔中分离出的301株酵母菌对茶树油的敏感性。所有测试的分离株均敏感，包括41株已知对氟康唑和伊曲康唑均耐药的菌株。茶树油作为免疫功能低下患者口腔真菌感染预防和治疗药物的临床研究值得考虑。
