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茶树油（互叶白千层）对氟康唑抗氟康唑耐药白色念珠菌菌株活性的影响。

The influence of tea tree oil (Melaleuca alternifolia) on fluconazole activity against fluconazole-resistant Candida albicans strains.

作者信息

Mertas Anna, Garbusińska Aleksandra, Szliszka Ewelina, Jureczko Andrzej, Kowalska Magdalena, Król Wojciech

机构信息

Department of Microbiology and Immunology, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland.

出版信息

Biomed Res Int. 2015;2015:590470. doi: 10.1155/2015/590470. Epub 2015 Feb 4.

DOI:10.1155/2015/590470
PMID:25722982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4334616/
Abstract

The aim of this study was to evaluate the activity of fluconazole against 32 clinical strains of fluconazole-resistant Candida albicans, and C. albicans ATCC 10231 reference strain, after their exposure to sublethal concentrations of tea tree oil (TTO) or its main bioactive component terpinen-4-ol. For all tested fluconazole-resistant C. albicans strains TTO and terpinen-4-ol minimal inhibitory concentrations (MICs) were low, ranging from 0.06% to 0.5%. The 24-hour exposure of fluconazole-resistant C. albicans strains to fluconazole with sublethal dose of TTO enhanced fluconazole activity against these strains. Overall, 62.5% of isolates were classified as susceptible, 25.0% exhibited intermediate susceptibility, and 12.5% were resistant. For all of the tested clinical strains the fluconazole MIC decreased from an average of 244.0 μg/mL to an average of 38.46 μg/mL, and the fluconazole minimal fungicidal concentrations (MFC) decreased from an average of 254.67 μg/mL to an average of 66.62 μg/mL. Terpinen-4-ol was found to be more active than TTO, and strongly enhanced fluconazole activity against fluconazole-resistant C. albicans strains. The results of this study demonstrate that combining natural substances such as TTO and conventional drug such as fluconazole, may help treat difficult yeast infections.

摘要

本研究的目的是评估氟康唑对32株耐氟康唑白色念珠菌临床菌株以及白色念珠菌ATCC 10231参考菌株在暴露于亚致死浓度的茶树油（TTO）或其主要生物活性成分萜品-4-醇后的活性。对于所有测试的耐氟康唑白色念珠菌菌株，TTO和萜品-4-醇的最低抑菌浓度（MIC）较低，范围为0.06%至0.5%。耐氟康唑白色念珠菌菌株在亚致死剂量的TTO存在下暴露于氟康唑24小时，增强了氟康唑对这些菌株的活性。总体而言，62.5%的分离株被分类为敏感，25.0%表现为中度敏感，12.5%为耐药。对于所有测试的临床菌株，氟康唑的MIC从平均244.0μg/mL降至平均38.46μg/mL，氟康唑的最低杀菌浓度（MFC）从平均254.67μg/mL降至平均66.62μg/mL。发现萜品-4-醇比TTO更具活性，并强烈增强了氟康唑对耐氟康唑白色念珠菌菌株的活性。本研究结果表明，将TTO等天然物质与氟康唑等传统药物联合使用，可能有助于治疗难治性酵母菌感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d93/4334616/8d75cd9c3489/BMRI2015-590470.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d93/4334616/8d75cd9c3489/BMRI2015-590470.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d93/4334616/8d75cd9c3489/BMRI2015-590470.001.jpg

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