Kogure S, Toda Y, Tsukahara S
Department of Ophthalmology, University of Yamanashi, Tamaho, Yamanashi 409-3898, Japan.
Br J Ophthalmol. 2006 Mar;90(3):347-52. doi: 10.1136/bjo.2005.077065.
To see if scotoma detected with frequency doubling technology (FDT) is confirmed by Humphrey field analyser (HFA) 3 years later.
Subjects were first examined with the screening C-20-1 program of FDT. The visual field was examined annually for 4 years using HFA program C30-2. The central 58 test points in HFA were assigned to one of the 17 clusters corresponding to FDT test points. Each cluster was represented as the lowest probability symbol of total deviation (TD) of the HFA test points included in the cluster. Clusters were graded normal, suspected scotoma, and scotoma depending on probability of TD-5% or more, 5%-1%, less than 1%, respectively. Relative risk (RR) of abnormality on FDT for future scotoma on HFA was estimated.
80 eyes of 42 patients were followed up for 4 years. While 4.0% of normal clusters of HFA with normal FDT results developed into scotoma cluster, 20.8% of normal clusters with abnormal FDT results developed into scotoma cluster with HFA at the third year. RR for future scotoma was 5.24 (95% CI, 2.75 to 10.0, p<0.05).
An abnormal result in FDT shows a high risk of future scotoma on HFA after 3 years even if the original HFA perimetry showed normal results.
观察3年后频率加倍技术（FDT）检测出的暗点是否能被 Humphrey 视野分析仪（HFA）所证实。
受试者首先用FDT的筛查C-20-1程序进行检查。使用HFA程序C30-2每年检查一次视野，共检查4年。将HFA中的中央58个测试点分配到与FDT测试点相对应的17个簇中的一个。每个簇用该簇中HFA测试点总偏差（TD）的最低概率符号表示。根据TD概率分别为5%或更高、5%-1%、小于1%，将簇分为正常、疑似暗点和暗点。估计FDT异常对未来HFA暗点的相对风险（RR）。
42例患者的80只眼随访4年。FDT结果正常的HFA正常簇中有4.0%发展为暗点簇，而FDT结果异常的正常簇在第三年有20.8%发展为HFA暗点簇。未来暗点的RR为5.24（95%CI，2.75至10.0，p<0.05）。
即使最初的HFA视野检查结果正常，FDT异常结果显示3年后未来HFA出现暗点的风险很高。
